Genetic and epigenetic basis of hepatoblastoma diversity

Genetic and epigenetic basis of hepatoblastoma diversity

While hepatoblastoma is the most common pediatric liver cancer, its molecular background has not been fully characterised. Here, the authors perform genomic and epigenomic profiling of 163 untreated pediatric liver tumours and suggest the upregulation of ASCL2 and methylation patterns of IGF2 promot...

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Bibliographic Details
Main Authors: Genta Nagae, Shogo Yamamoto, Masashi Fujita, Takanori Fujita, Aya Nonaka, Takayoshi Umeda, Shiro Fukuda, Kenji Tatsuno, Kazuhiro Maejima, Akimasa Hayashi, Sho Kurihara, Masato Kojima, Tomoro Hishiki, Kenichiro Watanabe, Kohmei Ida, Michihiro Yano, Yoko Hiyama, Yukichi Tanaka, Takeshi Inoue, Hiroki Ueda, Hidewaki Nakagawa, Hiroyuki Aburatani, Eiso Hiyama
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25430-9

Internet

https://doi.org/10.1038/s41467-021-25430-9

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