Deep immunophenotyping at the single-cell level identifies a combination of anti-IL-17 and checkpoint blockade as an effective treatment in a preclinical model of data-guided perso...

by Yukari Kobayashi, Kazuhiro Kakimi, Koji Nagaoka, Akihiro Hosoi, Masataka Shirai, Kiyomi Taniguchi, Changbo Sun, Kazuhiro Maejima, Hidewaki Nakagawa, Sachiyo Nomura
Published 2020-07-01

Molecular Classification and Tumor Microenvironment Characterization of Gallbladder Cancer by Comprehensive Genomic and Transcriptomic Analysis

by Nobutaka Ebata, Masashi Fujita, Shota Sasagawa, Kazuhiro Maejima, Yuki Okawa, Yutaka Hatanaka, Tomoko Mitsuhashi, Ayako Oosawa-Tatsuguchi, Hiroko Tanaka, Satoru Miyano, Toru Nakamura, Satoshi Hirano, Hidewaki Nakagawa
Published 2021-02-01

Analyses of putative anti-cancer potential of three STAT3 signaling inhibitory compounds derived from Salvia officinalis

by Maho Yanagimichi, Katsutoshi Nishino, Akiho Sakamoto, Ryusei Kurodai, Kenji Kojima, Nozomu Eto, Hiroko Isoda, Riadh Ksouri, Kazuhiro Irie, Taiho Kambe, Seiji Masuda, Toru Akita, Kazuhiro Maejima, Masaya Nagao
Published 2021-03-01

Whole genome sequencing analysis identifies recurrent structural alterations in esophageal squamous cell carcinoma

by Munmee Dutta, Hidewaki Nakagawa, Hiroaki Kato, Kazuhiro Maejima, Shota Sasagawa, Kaoru Nakano, Aya Sasaki-Oku, Akihiro Fujimoto, Raúl Nicolás Mateos, Ashwini Patil, Hiroko Tanaka, Satoru Miyano, Takushi Yasuda, Kenta Nakai, Masashi Fujita
Published 2020-06-01

RB1 Methylation by SMYD2 Enhances Cell Cycle Progression through an Increase of RB1 Phosphorylation

by Hyun-Soo Cho, Shinya Hayami, Gouji Toyokawa, Kazuhiro Maejima, Yuka Yamane, Takehiro Suzuki, Naoshi Dohmae, Masaharu Kogure, Daechun Kang, David E. Neal, Bruce A.J. Ponder, Hiroki Yamaue, Yusuke Nakamura, Ryuji Hamamoto
Published 2012-06-01

Genomic analysis of pancreatic juice DNA assesses malignant risk of intraductal papillary mucinous neoplasm of pancreas

by Raúl N. Mateos, Hidewaki Nakagawa, Seiko Hirono, Shinichi Takano, Mitsuharu Fukasawa, Akio Yanagisawa, Satoru Yasukawa, Kazuhiro Maejima, Aya Oku‐Sasaki, Kaoru Nakano, Munmee Dutta, Hiroko Tanaka, Satoru Miyano, Nobuyuki Enomoto, Hiroki Yamaue, Kenta Nakai, Masashi Fujita
Published 2019-08-01

Whole Genome Sequencing of a Vietnamese Family from a Dioxin Contamination Hotspot Reveals Novel Variants in the Son with Undiagnosed Intellectual Disability

by Dang Ton Nguyen, Hai Ha Nguyen, Thuy Duong Nguyen, Thi Thanh Hoa Nguyen, Kaoru Nakano, Kazuhiro Maejima, Aya Sasaki-Oku, Van Ba Nguyen, Duy Bac Nguyen, Bach Quang Le, Jing Hao Wong, Tatsuhiko Tsunoda, Hidewaki Nakagawa, Akihiro Fujimoto, Van Hai Nong
Published 2018-11-01

Classification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations

by Masashi Fujita, Rui Yamaguchi, Takanori Hasegawa, Shu Shimada, Koji Arihiro, Shuto Hayashi, Kazuhiro Maejima, Kaoru Nakano, Akihiro Fujimoto, Atsushi Ono, Hiroshi Aikata, Masaki Ueno, Shinya Hayami, Hiroko Tanaka, Satoru Miyano, Hiroki Yamaue, Kazuaki Chayama, Kazuhiro Kakimi, Shinji Tanaka, Seiya Imoto, Hidewaki Nakagawa
Published 2020-03-01

Genetic and epigenetic basis of hepatoblastoma diversity

by Genta Nagae, Shogo Yamamoto, Masashi Fujita, Takanori Fujita, Aya Nonaka, Takayoshi Umeda, Shiro Fukuda, Kenji Tatsuno, Kazuhiro Maejima, Akimasa Hayashi, Sho Kurihara, Masato Kojima, Tomoro Hishiki, Kenichiro Watanabe, Kohmei Ida, Michihiro Yano, Yoko Hiyama, Yukichi Tanaka, Takeshi Inoue, Hiroki Ueda, Hidewaki Nakagawa, Hiroyuki Aburatani, Eiso Hiyama
Published 2021-09-01

12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population

by Ryo Takata, Atsushi Takahashi, Masashi Fujita, Yukihide Momozawa, Edward J. Saunders, Hiroki Yamada, Kazuhiro Maejima, Kaoru Nakano, Yuichiro Nishida, Asahi Hishida, Keitaro Matsuo, Kenji Wakai, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane, Makoto Sasaki, Atsushi Shimizu, Kozo Tanno, Naoko Minegishi, Kichiya Suzuki, Koichi Matsuda, Michiaki Kubo, Johji Inazawa, Shin Egawa, Christopher A. Haiman, Osamu Ogawa, Wataru Obara, Yoichiro Kamatani, Shusuke Akamatsu, Hidewaki Nakagawa
Published 2019-09-01

Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers.

by Yuichi Shiraishi, Akihiro Fujimoto, Mayuko Furuta, Hiroko Tanaka, Ken-ichi Chiba, Keith A Boroevich, Tetsuo Abe, Yoshiiku Kawakami, Masaki Ueno, Kunihito Gotoh, Shun-ichi Ariizumi, Tetsuo Shibuya, Kaoru Nakano, Aya Sasaki, Kazuhiro Maejima, Rina Kitada, Shinya Hayami, Yoshinobu Shigekawa, Shigeru Marubashi, Terumasa Yamada, Michiaki Kubo, Osamu Ishikawa, Hiroshi Aikata, Koji Arihiro, Hideki Ohdan, Masakazu Yamamoto, Hiroki Yamaue, Kazuaki Chayama, Tatsuhiko Tsunoda, Satoru Miyano, Hidewaki Nakagawa
Published 2014-01-01