Three Structural Features of Functional Food Components and Herbal Medicine with Amyloid β42 Anti-Aggregation Properties

by Kazuma Murakami, Kazuhiro Irie
Published 2019-06-01

Possible Contribution of Zerumbone-Induced Proteo-Stress to Its Anti-Inflammatory Functions via the Activation of Heat Shock Factor 1.

by Yoko Igarashi, Kohta Ohnishi, Kazuhiro Irie, Akira Murakami
Published 2016-01-01

Evaluation of Toxic Amyloid β42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator

by Kazuma Murakami, Mayuko Yoshimura, Shota Nakagawa, Toshiaki Kume, Takayuki Kondo, Haruhisa Inoue, Kazuhiro Irie
Published 2020-02-01

Two Types of PPARγ Ligands Identified in the Extract of <i>Artemisia campestris</i>

by Tokio Hasegawa, Mayo Osaka, Yusaku Miyamae, Katsutoshi Nishino, Hiroko Isoda, Kiyokazu Kawada, Mohamed Neffati, Kazuhiro Irie, Masaya Nagao
Published 2021-05-01

A New Lyngbyatoxin from the Hawaiian Cyanobacterium Moorea producens

by Weina Jiang, Wei Zhou, Hajime Uchida, Masayuki Kikumori, Kazuhiro Irie, Ryuichi Watanabe, Toshiyuki Suzuki, Bryan Sakamoto, Michiya Kamio, Hiroshi Nagai
Published 2014-05-01

Two New Lyngbyatoxin Derivatives from the Cyanobacterium, Moorea producens

by Weina Jiang, Satoshi Tan, Yusuke Hanaki, Kazuhiro Irie, Hajime Uchida, Ryuichi Watanabe, Toshiyuki Suzuki, Bryan Sakamoto, Michiya Kamio, Hiroshi Nagai
Published 2014-12-01

E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity

by Takayuki Suzuki, Kazuma Murakami, Naotaka Izuo, Toshiaki Kume, Akinori Akaike, Tetsu Nagata, Tomoyuki Nishizaki, Takami Tomiyama, Hiroshi Takuma, Hiroshi Mori, Kazuhiro Irie
Published 2011-01-01

Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model

by Tomohiro Imamura, Yuki T. Yanagihara, Yasumasa Ohyagi, Norimichi Nakamura, Kyoko M. Iinuma, Ryo Yamasaki, Hirohide Asai, Masahiro Maeda, Kazuma Murakami, Kazuhiro Irie, Jun-ichi Kira
Published 2020-04-01

Analyses of putative anti-cancer potential of three STAT3 signaling inhibitory compounds derived from Salvia officinalis

by Maho Yanagimichi, Katsutoshi Nishino, Akiho Sakamoto, Ryusei Kurodai, Kenji Kojima, Nozomu Eto, Hiroko Isoda, Riadh Ksouri, Kazuhiro Irie, Taiho Kambe, Seiji Masuda, Toru Akita, Kazuhiro Maejima, Masaya Nagao
Published 2021-03-01

Non-specific protein modifications by a phytochemical induce heat shock response for self-defense.

by Kohta Ohnishi, Shinya Ohkura, Erina Nakahata, Akari Ishisaka, Yoshichika Kawai, Junji Terao, Taiki Mori, Takeshi Ishii, Tsutomu Nakayama, Noriyuki Kioka, Shinya Matsumoto, Yasutaka Ikeda, Minoru Akiyama, Kazuhiro Irie, Akira Murakami
Published 2013-01-01

Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones

by Kento Tsukada, Shono Shinki, Akiho Kaneko, Kazuma Murakami, Kazuhiro Irie, Masatoshi Murai, Hideto Miyoshi, Shingo Dan, Kumi Kawaji, Hironori Hayashi, Eiichi N. Kodama, Aki Hori, Emil Salim, Takayuki Kuraishi, Naoya Hirata, Yasunari Kanda, Teigo Asai
Published 2020-04-01