Age-related disease association of endogenous γ-H2AX foci in mononuclear cells derived from leukapheresis.

Age-related disease association of endogenous γ-H2AX foci in mononuclear cells derived from leukapheresis.

The phosphorylated form of histone H2AX (γ-H2AX) forms immunohistochemically detectable foci at DNA double strand breaks. In peripheral blood mononuclear cells (PBMCs) derived from leukapheresis from patients enrolled in the Baltimore Longitudinal Study of Aging, γ-H2AX foci increased in a linear fa...

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Bibliographic Details
Main Authors: Shepherd H Schurman, Christopher A Dunn, Rebecca Greaves, Binbing Yu, Luigi Ferrucci, Deborah L Croteau, Michael M Seidman, Vilhelm A Bohr
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3448703?pdf=render

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http://europepmc.org/articles/PMC3448703?pdf=render

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