Age-related disease association of endogenous γ-H2AX foci in mononuclear cells derived from leukapheresis.
The phosphorylated form of histone H2AX (γ-H2AX) forms immunohistochemically detectable foci at DNA double strand breaks. In peripheral blood mononuclear cells (PBMCs) derived from leukapheresis from patients enrolled in the Baltimore Longitudinal Study of Aging, γ-H2AX foci increased in a linear fa...
Main Authors: | Shepherd H Schurman, Christopher A Dunn, Rebecca Greaves, Binbing Yu, Luigi Ferrucci, Deborah L Croteau, Michael M Seidman, Vilhelm A Bohr |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3448703?pdf=render |
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