Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging
Sensitive and label-free imaging methods to visualize nerve degeneration are currently lacking. Here authors show that stimulated Raman scattering (SRS) microscopy can be used to monitor peripheral nerve degeneration in mouse models of amyotrophic lateral sclerosis (ALS) and in postmortem tissue fro...
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| Language: | English |
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Nature Publishing Group
2016-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13283 |
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doaj-60127ef2c8cc4a6295abca6013b566132021-05-11T11:13:49ZengNature Publishing GroupNature Communications2041-17232016-10-017111510.1038/ncomms13283Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imagingFeng Tian0Wenlong Yang1Daniel A. Mordes2Jin-Yuan Wang3Johnny S. Salameh4Joanie Mok5Jeannie Chew6Aarti Sharma7Ester Leno-Duran8Satomi Suzuki-Uematsu9Naoki Suzuki10Steve S. Han11Fa-Ke Lu12Minbiao Ji13Rosanna Zhang14Yue Liu15Jack Strominger16Neil A. Shneider17Leonard Petrucelli18X. Sunney Xie19Kevin Eggan20Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard UniversityDepartment of Chemistry and Chemical Biology, Harvard UniversityDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard UniversityDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard UniversityDepartment of Neurology, University of Massachusetts Memorial Medical CenterDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard UniversityDepartment of Neuroscience, Mayo ClinicDepartment of Neurology, Columbia University Medical CenterDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard UniversityDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard UniversityDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard UniversityDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard UniversityDepartment of Chemistry and Chemical Biology, Harvard UniversityDepartment of Chemistry and Chemical Biology, Harvard UniversityDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard UniversityDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard UniversityDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard UniversityDepartment of Neurology, Columbia University Medical CenterDepartment of Neuroscience, Mayo ClinicDepartment of Chemistry and Chemical Biology, Harvard UniversityDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard UniversitySensitive and label-free imaging methods to visualize nerve degeneration are currently lacking. Here authors show that stimulated Raman scattering (SRS) microscopy can be used to monitor peripheral nerve degeneration in mouse models of amyotrophic lateral sclerosis (ALS) and in postmortem tissue from ALS patients.https://doi.org/10.1038/ncomms13283 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Feng Tian Wenlong Yang Daniel A. Mordes Jin-Yuan Wang Johnny S. Salameh Joanie Mok Jeannie Chew Aarti Sharma Ester Leno-Duran Satomi Suzuki-Uematsu Naoki Suzuki Steve S. Han Fa-Ke Lu Minbiao Ji Rosanna Zhang Yue Liu Jack Strominger Neil A. Shneider Leonard Petrucelli X. Sunney Xie Kevin Eggan |
| spellingShingle |
Feng Tian Wenlong Yang Daniel A. Mordes Jin-Yuan Wang Johnny S. Salameh Joanie Mok Jeannie Chew Aarti Sharma Ester Leno-Duran Satomi Suzuki-Uematsu Naoki Suzuki Steve S. Han Fa-Ke Lu Minbiao Ji Rosanna Zhang Yue Liu Jack Strominger Neil A. Shneider Leonard Petrucelli X. Sunney Xie Kevin Eggan Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging Nature Communications |
| author_facet |
Feng Tian Wenlong Yang Daniel A. Mordes Jin-Yuan Wang Johnny S. Salameh Joanie Mok Jeannie Chew Aarti Sharma Ester Leno-Duran Satomi Suzuki-Uematsu Naoki Suzuki Steve S. Han Fa-Ke Lu Minbiao Ji Rosanna Zhang Yue Liu Jack Strominger Neil A. Shneider Leonard Petrucelli X. Sunney Xie Kevin Eggan |
| author_sort |
Feng Tian |
| title |
Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging |
| title_short |
Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging |
| title_full |
Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging |
| title_fullStr |
Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging |
| title_full_unstemmed |
Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging |
| title_sort |
monitoring peripheral nerve degeneration in als by label-free stimulated raman scattering imaging |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-10-01 |
| description |
Sensitive and label-free imaging methods to visualize nerve degeneration are currently lacking. Here authors show that stimulated Raman scattering (SRS) microscopy can be used to monitor peripheral nerve degeneration in mouse models of amyotrophic lateral sclerosis (ALS) and in postmortem tissue from ALS patients. |
| url |
https://doi.org/10.1038/ncomms13283 |
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