The Histone-H3K4-Specific Demethylase KDM5B Binds to Its Substrate and Product through Distinct PHD Fingers

The Histone-H3K4-Specific Demethylase KDM5B Binds to Its Substrate and Product through Distinct PHD Fingers

The histone lysine demethylase KDM5B regulates gene transcription and cell differentiation and is implicated in carcinogenesis. It contains multiple conserved chromatin-associated domains, including three PHD fingers of unknown function. Here, we show that the first and third, but not the second, PH...

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Bibliographic Details
Main Authors: Brianna J. Klein, Lianhua Piao, Yuanxin Xi, Hector Rincon-Arano, Scott B. Rothbart, Danni Peng, Hong Wen, Connie Larson, Xi Zhang, Xia Zheng, Michael A. Cortazar, Pedro V. Peña, Anthony Mangan, David L. Bentley, Brian D. Strahl, Mark Groudine, Wei Li, Xiaobing Shi, Tatiana G. Kutateladze
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713007663

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http://www.sciencedirect.com/science/article/pii/S2211124713007663

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