A Degenerate Peptide Library Approach to Reveal Sequence Determinants of Methyllysine-Driven Protein Interactions

by Ariana Kupai, Robert M. Vaughan, Bradley M. Dickson, Scott B. Rothbart
Published 2020-04-01

The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer

by Nicolas Veland, Swanand Hardikar, Yi Zhong, Sitaram Gayatri, Jiameng Dan, Brian D. Strahl, Scott B. Rothbart, Mark T. Bedford, Taiping Chen
Published 2017-12-01

An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1

by Zhi-Min Zhang, Scott B. Rothbart, David F. Allison, Qian Cai, Joseph S. Harrison, Lin Li, Yinsheng Wang, Brian D. Strahl, Gang Greg Wang, Jikui Song
Published 2015-09-01

A Read/Write Mechanism Connects p300 Bromodomain Function to H2A.Z Acetylation

by Yolanda Colino-Sanguino, Evan M. Cornett, David Moulder, Grady C. Smith, Joel Hrit, Eric Cordeiro-Spinetti, Robert M. Vaughan, Krzysztof Krajewski, Scott B. Rothbart, Susan J. Clark, Fátima Valdés-Mora
Published 2019-11-01

Dido3 PHD Modulates Cell Differentiation and Division

by Jovylyn Gatchalian, Agnes Fütterer, Scott B. Rothbart, Qiong Tong, Hector Rincon-Arano, Ainhoa Sánchez de Diego, Mark Groudine, Brian D. Strahl, Carlos Martínez-A, Karel H.M. van Wely, Tatiana G. Kutateladze
Published 2013-07-01

A Histone Methylation Network Regulates Transgenerational Epigenetic Memory in C. elegans

by Eric L. Greer, Sara E. Beese-Sims, Emily Brookes, Ruggero Spadafora, Yun Zhu, Scott B. Rothbart, David Aristizábal-Corrales, Shuzhen Chen, Aimee I. Badeaux, Qiuye Jin, Wei Wang, Brian D. Strahl, Monica P. Colaiácovo, Yang Shi
Published 2014-04-01

Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase

by Forest H. Andrews, Qiong Tong, Kelly D. Sullivan, Evan M. Cornett, Yi Zhang, Muzaffar Ali, JaeWoo Ahn, Ahway Pandey, Angela H. Guo, Brian D. Strahl, James C. Costello, Joaquin M. Espinosa, Scott B. Rothbart, Tatiana G. Kutateladze
Published 2016-09-01

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF

by Yi Zhang, Younghoon Jang, Ji-Eun Lee, JaeWoo Ahn, Longxia Xu, Michael R. Holden, Evan M. Cornett, Krzysztof Krajewski, Brianna J. Klein, Shu-Ping Wang, Yali Dou, Robert G. Roeder, Brian D. Strahl, Scott B. Rothbart, Xiaobing Shi, Kai Ge, Tatiana G. Kutateladze
Published 2019-05-01

The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cel...

by Robert M. Vaughan, Ariana Kupai, Caroline A. Foley, Cari A. Sagum, Bailey M. Tibben, Hope E. Eden, Rochelle L. Tiedemann, Christine A. Berryhill, Varun Patel, Kevin M. Shaw, Krzysztof Krajewski, Brian D. Strahl, Mark T. Bedford, Stephen V. Frye, Bradley M. Dickson, Scott B. Rothbart
Published 2020-10-01

The Histone-H3K4-Specific Demethylase KDM5B Binds to Its Substrate and Product through Distinct PHD Fingers

by Brianna J. Klein, Lianhua Piao, Yuanxin Xi, Hector Rincon-Arano, Scott B. Rothbart, Danni Peng, Hong Wen, Connie Larson, Xi Zhang, Xia Zheng, Michael A. Cortazar, Pedro V. Peña, Anthony Mangan, David L. Bentley, Brian D. Strahl, Mark Groudine, Wei Li, Xiaobing Shi, Tatiana G. Kutateladze
Published 2014-01-01

Identification of a BET Family Bromodomain/Casein Kinase II/TAF-Containing Complex as a Regulator of Mitotic Condensin Function

by Hyun-Soo Kim, Rituparna Mukhopadhyay, Scott B. Rothbart, Andrea C. Silva, Vincent Vanoosthuyse, Ernest Radovani, Thomas Kislinger, Assen Roguev, Colm J. Ryan, Jiewei Xu, Harlizawati Jahari, Kevin G. Hardwick, Jack F. Greenblatt, Nevan J. Krogan, Jeffrey S. Fillingham, Brian D. Strahl, Eric E. Bouhassira, Winfried Edelmann, Michael-Christopher Keogh
Published 2014-03-01

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

by Jennifer L Franks, Raquel C Martinez-Chacin, Xianxi Wang, Rochelle L Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L Bolhuis, Taylor P Enrico, Ryan D Mouery, Jeffrey S Damrauer, Feng Yan, Joseph S Harrison, M Ben Major, Katherine A Hoadley, Aussie Suzuki, Scott B Rothbart, Nicholas G Brown, Michael J Emanuele
Published 2020-12-01

Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1

by Joseph S Harrison, Evan M Cornett, Dennis Goldfarb, Paul A DaRosa, Zimeng M Li, Feng Yan, Bradley M Dickson, Angela H Guo, Daniel V Cantu, Lilia Kaustov, Peter J Brown, Cheryl H Arrowsmith, Dorothy A Erie, Michael B Major, Rachel E Klevit, Krzysztof Krajewski, Brian Kuhlman, Brian D Strahl, Scott B Rothbart
Published 2016-09-01