Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

Abstract Background Misfolding and aggregation of the presynaptic protein alpha-synuclein (αsyn) is a hallmark of Parkinson’s disease (PD) and related synucleinopathies. Although predominantly localized in the cytosol, a body of evidence has shown that αsyn localizes to mitochondria and contributes...

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Bibliographic Details
Main Authors: Jae-Hyeon Park, Jeremy D. Burgess, Ayman H. Faroqi, Natasha N. DeMeo, Fabienne C. Fiesel, Wolfdieter Springer, Marion Delenclos, Pamela J. McLean
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Molecular Neurodegeneration
Subjects:
α-Synuclein
Sirtuin 3
Mitochondria dysfunction
Parkinson’s disease
Online Access:https://doi.org/10.1186/s13024-019-0349-x

Internet

https://doi.org/10.1186/s13024-019-0349-x

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