GATA-targeted compounds modulate cardiac subtype cell differentiation in dual reporter stem cell line

GATA-targeted compounds modulate cardiac subtype cell differentiation in dual reporter stem cell line

Abstract Background Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. Compounds that target tissue-specific transcription factors could overcome non-specific effects of small molecules and lead to the regene...

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Bibliographic Details
Main Authors: Mika J. Välimäki, Robert S. Leigh, Sini M. Kinnunen, Alexander R. March, Ana Hernández de Sande, Matias Kinnunen, Markku Varjosalo, Merja Heinäniemi, Bogac L. Kaynak, Heikki Ruskoaho
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Stem Cell Research & Therapy
Subjects:
Stem cells
Cardiomyocyte subtype
Atrial cardiomyocyte
Ventricular cardiomyocyte
Heart regeneration
GATA4
Online Access:https://doi.org/10.1186/s13287-021-02259-z

Internet

https://doi.org/10.1186/s13287-021-02259-z

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