Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis

Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis

Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1) is commonly downregulated in human cancers through promoter methylation. We proposed that ALDH1L1 loss promotes malignant tumor growth. Here, we investigated the effect of the <i>Aldh1l1</i> mouse knockout (<i>Aldh1l1<s...

Full description

Bibliographic Details
Main Authors: Natalia I. Krupenko, Jaspreet Sharma, Halle M. Fogle, Peter Pediaditakis, Kyle C. Strickland, Xiuxia Du, Kristi L. Helke, Susan Sumner, Sergey A. Krupenko
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
ALDH1L1
mouse knockout
folate metabolism
liver cancer
diethylnitrosamine (DEN) carcinogenesis
metabolomics
Online Access:https://www.mdpi.com/2072-6694/13/13/3219

Internet

https://www.mdpi.com/2072-6694/13/13/3219

Similar Items