Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery.
Ebola Zaire virus is highly pathogenic for humans, with case fatality rates approaching 90% in large outbreaks in Africa. The virus replicates in macrophages and dendritic cells (DCs), suppressing production of type I interferons (IFNs) while inducing the release of large quantities of proinflammato...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-06-01
|
Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC2696038?pdf=render |