Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery.

Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery.

Ebola Zaire virus is highly pathogenic for humans, with case fatality rates approaching 90% in large outbreaks in Africa. The virus replicates in macrophages and dendritic cells (DCs), suppressing production of type I interferons (IFNs) while inducing the release of large quantities of proinflammato...

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Bibliographic Details
Main Authors: Tsung-Hsien Chang, Toru Kubota, Mayumi Matsuoka, Steven Jones, Steven B Bradfute, Mike Bray, Keiko Ozato
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2696038?pdf=render

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http://europepmc.org/articles/PMC2696038?pdf=render

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