Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations

Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations

Abstract Cerebral cavernous malformations (CCMs) are vascular lesions in the central nervous system causing strokes and seizures which currently can only be treated through neurosurgery. The disease arises through changes in the regulatory networks of endothelial cells that must be comprehensively u...

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Bibliographic Details
Main Authors: Cécile Otten, Jessica Knox, Gwénola Boulday, Mathias Eymery, Marta Haniszewski, Martin Neuenschwander, Silke Radetzki, Ingo Vogt, Kristina Hähn, Coralie De Luca, Cécile Cardoso, Sabri Hamad, Carla Igual Gil, Peter Roy, Corinne Albiges‐Rizo, Eva Faurobert, Jens P vonKries, Mónica Campillos, Elisabeth Tournier‐Lasserve, W Brent Derry, Salim Abdelilah‐Seyfried
Format: Article
Language:English
Published: Wiley 2018-10-01
Series:EMBO Molecular Medicine
Subjects:
angiogenesis
CCM
ERK5
indirubin‐3‐monoxime
KLF2
Online Access:https://doi.org/10.15252/emmm.201809155

Internet

https://doi.org/10.15252/emmm.201809155

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