Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function

Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function

Summary: Pancreatic β cell physiology changes substantially throughout life, yet the mechanisms that drive these changes are poorly understood. Here, we performed comprehensive in vivo quantitative proteomic profiling of pancreatic islets from juvenile and 1-year-old mice. The analysis revealed stri...

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Bibliographic Details
Main Authors: Matthew Wortham, Jacqueline R. Benthuysen, Martina Wallace, Jeffrey N. Savas, Francesca Mulas, Ajit S. Divakaruni, Fenfen Liu, Verena Albert, Brandon L. Taylor, Yinghui Sui, Enrique Saez, Anne N. Murphy, John R. Yates, III, Christian M. Metallo, Maike Sander
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718317777

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http://www.sciencedirect.com/science/article/pii/S2211124718317777

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