Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture

Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture

Multiple obligatory intracellular bacteria in the genus Chlamydia are important pathogens. In humans, strains of C. trachomatis cause trachoma, chlamydia, and lymphogranuloma venereum. These diseases are all associated with extended courses of infection and reinfection that likely reflect the abilit...

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Bibliographic Details
Main Authors: Amanda M. Giebel, Shuai Hu, Krithika Rajaram, Ryan Finethy, Evelyn Toh, Julie A. Brothwell, Sandra G. Morrison, Robert J. Suchland, Barry D. Stein, Jörn Coers, Richard P. Morrison, David E. Nelson
Format: Article
Language:English
Published: American Society for Microbiology 2019-04-01
Series:mBio
Subjects:
Chlamydia
host-pathogen interactions
interferon-stimulated genes
intracellular pathogens
molecular genetics
Online Access:https://doi.org/10.1128/mBio.00385-19

Internet

https://doi.org/10.1128/mBio.00385-19

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