4E‐BP1 and 4E‐BP2 double knockout mice are protected from aging‐associated sarcopenia

4E‐BP1 and 4E‐BP2 double knockout mice are protected from aging‐associated sarcopenia

Abstract Background Sarcopenia is the loss of muscle mass/function that occurs during the aging process. The links between mechanistic target of rapamycin (mTOR) activity and muscle development are largely documented, but the role of its downstream targets in the development of sarcopenia is poorly...

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Bibliographic Details
Main Authors: Olivier Le Bacquer, Kristell Combe, Véronique Patrac, Brian Ingram, Lydie Combaret, Dominique Dardevet, Christophe Montaurier, Jérôme Salles, Christophe Giraudet, Christelle Guillet, Nahum Sonenberg, Yves Boirie, Stéphane Walrand
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Anabolism
mTOR
Protein synthesis
Proteolysis
Skeletal muscle
Online Access:https://doi.org/10.1002/jcsm.12412

Internet

https://doi.org/10.1002/jcsm.12412

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