Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.

Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.

Vaccinia virus (VACV), the prototype poxvirus, encodes numerous proteins that modulate the host response to infection. Two such proteins, B14 and A52, act inside infected cells to inhibit activation of NF-kappaB, thereby blocking the production of pro-inflammatory cytokines. We have solved the cryst...

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Bibliographic Details
Main Authors: Stephen C Graham, Mohammad W Bahar, Samantha Cooray, Ron A-J Chen, Daniel M Whalen, Nicola G A Abrescia, David Alderton, Raymond J Owens, David I Stuart, Geoffrey L Smith, Jonathan M Grimes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-08-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18704168/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18704168/?tool=EBI

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