HMGB1 and its membrane receptors as therapeutic targets in an intravesical substance P-induced bladder pain syndrome mouse model

HMGB1 and its membrane receptors as therapeutic targets in an intravesical substance P-induced bladder pain syndrome mouse model

HMGB1, a nuclear protein, once released to the extracellular space, promotes somatic and visceral pain signals. We thus analyzed the role of HMGB1 in an intravesical substance P-induced bladder pain syndrome (BPS) mouse model. Intravesical administration of substance P caused referred hyperalgesia/a...

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Bibliographic Details
Main Authors: Yuhei Irie, Maho Tsubota, Mariko Maeda, Shiori Hiramoto, Fumiko Sekiguchi, Hiroyasu Ishikura, Hidenori Wake, Masahiro Nishibori, Atsufumi Kawabata
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Journal of Pharmacological Sciences
Subjects:
HMGB1
Substance P
Bladder pain syndrome
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300293

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http://www.sciencedirect.com/science/article/pii/S1347861320300293

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