Role of 3'UTRs in the translation of mRNAs regulated by oncogenic eIF4E--a computational inference.

Role of 3'UTRs in the translation of mRNAs regulated by oncogenic eIF4E--a computational inference.

Eukaryotic cap-dependent mRNA translation is mediated by the initiation factor eIF4E, which binds mRNAs and stimulates efficient translation initiation. eIF4E is often overexpressed in human cancers. To elucidate the molecular signature of eIF4E target mRNAs, we analyzed sequence and structural prop...

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Bibliographic Details
Main Authors: Arti N Santhanam, Eckart Bindewald, Vinagolu K Rajasekhar, Ola Larsson, Nahum Sonenberg, Nancy H Colburn, Bruce A Shapiro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2654073?pdf=render

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http://europepmc.org/articles/PMC2654073?pdf=render

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