Inhibition of Membrane Na+ Channels by A Type Botulinum Toxin at Femtomolar Concentrations in Central and Peripheral Neurons

Inhibition of Membrane Na+ Channels by A Type Botulinum Toxin at Femtomolar Concentrations in Central and Peripheral Neurons

Recent studies have demonstrated that the botulinum neurotoxins inhibit the release of acetylcholine, glutamate, GABA, and glycine in central nerve system (CNS) neurons. The Na+ current (INa) is of major interest because it acts as the trigger for many cellular functions such as transmission, secret...

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Bibliographic Details
Main Authors: Min-Chul Shin, Masahito Wakita, Du-Jie Xie, Toshitaka Yamaga, Satomi Iwata, Yasushi Torii, Tetsuhiro Harakawa, Akihiro Ginnaga, Shunji Kozaki, Norio Akaike
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319305961

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http://www.sciencedirect.com/science/article/pii/S1347861319305961

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