NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation

NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation

BRCA1 mutation carriers have higher chances of developing triple-negative breast cancer (TNBC). Here, the authors use the Sleeping Beauty mutagenesis system in Brca1 deficient mice and identify 169 putative driver genes, of which NOTCH1 accelerates TNBC formation through promoting epithelial-mesench...

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Bibliographic Details
Main Authors: Kai Miao, Josh Haipeng Lei, Monica Vishnu Valecha, Aiping Zhang, Jun Xu, Lijian Wang, Xueying Lyu, Si Chen, Zhengqiang Miao, Xin Zhang, Sek Man Su, Fangyuan Shao, Barani Kumar Rajendran, Jiaolin Bao, Jianming Zeng, Heng Sun, Ping Chen, Kaeling Tan, Qiang Chen, Koon Ho Wong, Xiaoling Xu, Chu-Xia Deng
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16936-9

Internet

https://doi.org/10.1038/s41467-020-16936-9

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