In Utero Administration of Drugs Targeting Microglia Improves the Neurodevelopmental Outcome Following Cytomegalovirus Infection of the Rat Fetal Brain

In Utero Administration of Drugs Targeting Microglia Improves the Neurodevelopmental Outcome Following Cytomegalovirus Infection of the Rat Fetal Brain

Congenital cytomegalovirus (CMV) infections represent one leading cause of neurodevelopmental disorders. Recently, we reported on a rat model of CMV infection of the developing brain in utero, characterized by early and prominent infection and alteration of microglia—the brain-resident mononuclear p...

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Bibliographic Details
Main Authors: Robin Cloarec, Sylvian Bauer, Natacha Teissier, Fabienne Schaller, Hervé Luche, Sandra Courtens, Manal Salmi, Vanessa Pauly, Emilie Bois, Emilie Pallesi-Pocachard, Emmanuelle Buhler, François J. Michel, Pierre Gressens, Marie Malissen, Thomas Stamminger, Daniel N. Streblow, Nadine Bruneau, Pierre Szepetowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cytomegalovirus
microglia
rat model
fetal brain
neurological outcome
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00055/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2018.00055/full

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