Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study

Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study

Background: Cognitive and motor task performance in premanifest Huntington's disease (HD) gene-carriers is often within normal ranges prior to clinical diagnosis, despite loss of brain volume in regions involved in these tasks. This indicates ongoing compensation, with the brain maintaining fun...

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Bibliographic Details
Main Authors: Stefan Klöppel, Sarah Gregory, Elisa Scheller, Lora Minkova, Adeel Razi, Alexandra Durr, Raymund A.C. Roos, Blair R. Leavitt, Marina Papoutsi, G. Bernhard Landwehrmeyer, Ralf Reilmann, Beth Borowsky, Hans Johnson, James A. Mills, Gail Owen, Julie Stout, Rachael I. Scahill, Jeffrey D. Long, Geraint Rees, Sarah J. Tabrizi
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:EBioMedicine
Subjects:
Huntington's disease
Preclinical
Neural compensation
MRI
Cognitive
Motor
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415300967

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http://www.sciencedirect.com/science/article/pii/S2352396415300967

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