Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy

Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy

Status epilepticus (SE) induces neuroinflammation and epileptogenesis, but the mechanisms are not yet fully delineated. The Fyn, a non-receptor Src family tyrosine kinase (SFK), and its immediate downstream target, PKCδ are emerging as potential mediators of neuroinflammation. In order to first dete...

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Bibliographic Details
Main Authors: Shaunik Sharma, Steven Carlson, Sreekanth Puttachary, Souvarish Sarkar, Lucas Showman, Marson Putra, Anumantha G. Kanthasamy, Thimmasettappa Thippeswamy
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Neurobiology of Disease
Subjects:
Microglia
Neuroinflammation
Status epilepticus
Epileptogenesis
Video-EEG
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611730270X

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http://www.sciencedirect.com/science/article/pii/S096999611730270X

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