Gata2 heterozygous mutant mice exhibit reduced inflammatory responses and impaired bacterial clearance

Summary: Infectious diseases continually pose global medical challenges. The transcription factor GATA2 establishes gene networks and defines cellular identity in hematopoietic stem/progenitor cells and in progeny committed to specific lineages. GATA2-haploinsufficient patients exhibit a spectrum of...

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Bibliographic Details
Main Authors: Jun Takai, Takashi Shimada, Tadaho Nakamura, James Douglas Engel, Takashi Moriguchi
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422100804X