Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo.

Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo.

Tumor cells exhibit an altered metabolism characterized by elevated aerobic glycolysis and lactate secretion which is supported by an increase in glucose transport and consumption. We hypothesized that reducing or eliminating the expression of the most prominently expressed glucose transporter(s) wo...

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Bibliographic Details
Main Authors: Christian D Young, Andrew S Lewis, Michael C Rudolph, Marisa D Ruehle, Matthew R Jackman, Ui J Yun, Olesya Ilkun, Renata Pereira, E Dale Abel, Steven M Anderson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3149640?pdf=render

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http://europepmc.org/articles/PMC3149640?pdf=render

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