Overexpression of Murine <i>Rnaset2</i> in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection

Overexpression of Murine <i>Rnaset2</i> in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection

Human RNASET2 acts as a powerful oncosuppressor protein in in vivo xenograft-based murine models of human cancer. Secretion of RNASET2 in the tumor microenvironment seems involved in tumor suppression, following recruitment of M1-polarized macrophages. Here, we report a murine <i>Rnaset2</i...

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Bibliographic Details
Main Authors: Annarosaria De Vito, Paola Orecchia, Enrica Balza, Daniele Reverberi, Debora Scaldaferri, Roberto Taramelli, Douglas M. Noonan, Francesco Acquati, Lorenzo Mortara
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
rnaset2
c51 colon carcinoma
m1/m2 macrophage ratio
tnfα-producing m1 macrophages
immune t cell responses
Online Access:https://www.mdpi.com/2072-6694/12/3/717

Internet

https://www.mdpi.com/2072-6694/12/3/717

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