MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

Summary: Recent studies have profiled the innate immune signatures in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and suggest that cellular responses to viral challenge may affect disease severity. Yet the molecular events that underlie cellular recognition an...

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Bibliographic Details
Main Authors: Xin Yin, Laura Riva, Yuan Pu, Laura Martin-Sancho, Jun Kanamune, Yuki Yamamoto, Kouji Sakai, Shimpei Gotoh, Lisa Miorin, Paul D. De Jesus, Chih-Cheng Yang, Kristina M. Herbert, Sunnie Yoh, Judd F. Hultquist, Adolfo García-Sastre, Sumit K. Chanda
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cell Reports
Subjects:
SARS-CoV-2
lung epithelial cells
interferon
MDA5
IRF3
IRF5
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472031617X

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http://www.sciencedirect.com/science/article/pii/S221112472031617X

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