A generic mechanism of emergence of amyloid protofilaments from disordered oligomeric aggregates.

The presence of oligomeric aggregates, which is often observed during the process of amyloid formation, has recently attracted much attention because it has been associated with a range of neurodegenerative conditions including Alzheimer's and Parkinson's diseases. We provide a description...

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Bibliographic Details
Main Authors: Stefan Auer, Filip Meersman, Christopher M Dobson, Michele Vendruscolo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-11-01
Series:PLoS Computational Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19008938/pdf/?tool=EBI