Potential Role of Phosphoglycerol Dihydroceramide Produced by Periodontal Pathogen Porphyromonas gingivalis in the Pathogenesis of Alzheimer’s Disease

Potential Role of Phosphoglycerol Dihydroceramide Produced by Periodontal Pathogen Porphyromonas gingivalis in the Pathogenesis of Alzheimer’s Disease

BackgroundAmong different types of sphingolipids produced by human cells, the possible engagement of ceramide species in the pathogenesis of Alzheimer’s disease (AD) has attracted recent attention. While ceramides are primarily generated by de novo synthesis in mammalian cells, only a limited number...

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Bibliographic Details
Main Authors: Chiaki Yamada, Juliet Akkaoui, Anny Ho, Carolina Duarte, Richard Deth, Toshihisa Kawai, Frank Nichols, Madepalli K. Lakshmana, Alexandru Movila
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
Alzheimer's Disease
Porphyromonas gingivalis
dihydroceramides
amyloid precursor protein
tau protein
cellular senescence
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.591571/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.591571/full

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