Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape

Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape

In most well-studied rod-shaped bacteria, peptidoglycan is primarily crosslinked by penicillin-binding proteins (PBPs). However, in mycobacteria, crosslinks formed by L,D-transpeptidases (LDTs) are highly abundant. To elucidate the role of these unusual crosslinks, we characterized Mycobacterium sme...

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Bibliographic Details
Main Authors: Catherine Baranowski, Michael A Welsh, Lok-To Sham, Haig A Eskandarian, Hoong Chuin Lim, Karen J Kieser, Jeffrey C Wagner, John D McKinney, Georg E Fantner, Thomas R Ioerger, Suzanne Walker, Thomas G Bernhardt, Eric J Rubin, E Hesper Rego
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
Mycobacterium tuberculosis
Mycobacterium smegmatis
peptidoglycan
polar growth
rod shape maintenance
Online Access:https://elifesciences.org/articles/37516

Internet

https://elifesciences.org/articles/37516

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