Development and Technical Validation of an Immunoassay for the Detection of APP<sub>669–711</sub> (Aβ<sub>−3–40</sub>) in Biological Samples

Development and Technical Validation of an Immunoassay for the Detection of APP<sub>669–711</sub> (Aβ<sub>−3–40</sub>) in Biological Samples

The ratio of amyloid precursor protein (APP)<sub>669–711</sub> (Aβ<sub>−3–40</sub>)/Aβ<sub>1–42</sub> in blood plasma was reported to represent a novel Alzheimer’s disease biomarker. Here, we describe the characterization of two antibodies against the N-terminus o...

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Bibliographic Details
Main Authors: Hans W. Klafki, Petra Rieper, Anja Matzen, Silvia Zampar, Oliver Wirths, Jonathan Vogelgsang, Dirk Osterloh, Lara Rohdenburg, Timo J. Oberstein, Olaf Jahn, Isaak Beyer, Ingolf Lachmann, Hans-Joachim Knölker, Jens Wiltfang
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
biomarker
amyloid β
assay development
assay validation
Online Access:https://www.mdpi.com/1422-0067/21/18/6564

Internet

https://www.mdpi.com/1422-0067/21/18/6564

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