Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease

Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease

Objective: Insulin resistance and altered hepatic mitochondrial function are central features of type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD), but the etiological role of these processes in disease progression remains unclear. Here we investigated the molecular links between i...

Full description

Bibliographic Details
Main Authors: Chris E. Shannon, Mukundan Ragavan, Juan Pablo Palavicini, Marcel Fourcaudot, Terry M Bakewell, Ivan A. Valdez, Iriscilla Ayala, Eunsook S. Jin, Muniswamy Madesh, Xianlin Han, Matthew E. Merritt, Luke Norton
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Metabolism
Subjects:
Insulin resistance
Metabolic liver disease
Mitochondria
Thiazolidinedione
Cardiolipin
Pyruvate dehydrogenase
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820302283

Internet

http://www.sciencedirect.com/science/article/pii/S2212877820302283

Similar Items