Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis

Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis

Nephrogenesis ceases after postnatal day 2 in the mouse or after the 36th week of gestation in humans, but how this is regulated is unclear. Here, the authors identify a role for the RNA-binding protein Lin28 and suppression of let-7 microRNA in regulating the duration of nephrogenesis.

Bibliographic Details
Main Authors: Alena V. Yermalovich, Jihan K. Osborne, Patricia Sousa, Areum Han, Melissa A. Kinney, Michael J. Chen, Daisy A. Robinton, Helen Montie, Dan S. Pearson, Sean B. Wilson, Alexander N. Combes, Melissa H. Little, George Q. Daley
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-08127-4

Internet

https://doi.org/10.1038/s41467-018-08127-4

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