Genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targeted.

Genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targeted.

Solid tumors, including head and neck squamous cell carcinomas (HNSCC), arise as a result of genetic and epigenetic alterations in a sustained stress environment. Little work has been done that simultaneously examines the spectrum of both types of changes in human tumors on a genome-wide scale and r...

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Bibliographic Details
Main Authors: Graham M Poage, Brock C Christensen, E Andres Houseman, Michael D McClean, John K Wiencke, Marshall R Posner, John R Clark, Heather H Nelson, Carmen J Marsit, Karl T Kelsey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2836370?pdf=render

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http://europepmc.org/articles/PMC2836370?pdf=render

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