John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y Receptors

John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y Receptors

We establish structure activity relationships of extracellular nucleosides and nucleotides at G protein-coupled receptors (GPCRs), e.g. adenosine receptors (ARs) and P2Y receptors (P2YRs), respectively. We synthesize selective agents for use as pharmacological probes and potential therapeutic agents...

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Bibliographic Details
Main Authors: Kenneth A. Jacobson, Zhan-Guo Gao, Silvia Paoletta, Evgeny Kiselev, Saibal Chakraborty, P. Suresh Jayasekara, Ramachandran Balasubramanian, Dilip K. Tosh
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
GPCR
Medicinal chemistry
Purines
X-ray structures
Nucleosides
Nucleotides
Polypharmacology
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037014000415

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http://www.sciencedirect.com/science/article/pii/S2001037014000415

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