Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary

Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary

Abstract Background Age-associated infertility is a problem worldwide, and management of oxidative stress is known to be essential. Nuclear factor-E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)-antioxidant response element (ARE) signaling pathway works as an essential defense...

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Bibliographic Details
Main Authors: Nana Akino, Osamu Wada-Hiraike, Wataru Isono, Hiromi Terao, Harunori Honjo, Yuichiro Miyamoto, Michihiro Tanikawa, Kenbun Sone, Mana Hirano, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Kaori Koga, Katsutoshi Oda, Tomoyuki Fujii, Yutaka Osuga
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Reproductive Biology and Endocrinology
Subjects:
Nrf2/Keap1
Dimethylfumarate
Oxidative stress
Ovarian reserve
Infertility
Online Access:http://link.springer.com/article/10.1186/s12958-019-0466-y

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http://link.springer.com/article/10.1186/s12958-019-0466-y

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