Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months

Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months

Keeping viral vaccines cold from the manufacturers to patients is problematic and costly. Here, Krol and others show additives that can significantly improve at very low concentrations the storage of adenovirus type 5 at ambient and elevated temperature.

Bibliographic Details
Main Authors: Maria Pelliccia, Patrizia Andreozzi, Jayson Paulose, Marco D’Alicarnasso, Valeria Cagno, Manuela Donalisio, Andrea Civra, Rebecca M. Broeckel, Nicole Haese, Paulo Jacob Silva, Randy P. Carney, Varpu Marjomäki, Daniel N. Streblow, David Lembo, Francesco Stellacci, Vincenzo Vitelli, Silke Krol
Format: Article
Language:English
Published: Nature Publishing Group 2016-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13520
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spelling doaj-6897222ac66a4957bef12c2b0a62fd792021-05-11T10:46:09ZengNature Publishing GroupNature Communications2041-17232016-11-01711710.1038/ncomms13520Additives for vaccine storage to improve thermal stability of adenoviruses from hours to monthsMaria Pelliccia0Patrizia Andreozzi1Jayson Paulose2Marco D’Alicarnasso3Valeria Cagno4Manuela Donalisio5Andrea Civra6Rebecca M. Broeckel7Nicole Haese8Paulo Jacob Silva9Randy P. Carney10Varpu Marjomäki11Daniel N. Streblow12David Lembo13Francesco Stellacci14Vincenzo Vitelli15Silke Krol16European School of Molecular Medicine (SEMM), IFOM-IEO-Campus, via Adamello 16, Milan 20139, ItalyFondazione I.R.C.C.S. Istituto Neurologico Carlo BestaInstituut-Lorentz for theoretical physics, Leiden UniversityEuropean School of Molecular Medicine (SEMM), IFOM-IEO-Campus, via Adamello 16, Milan 20139, ItalyDepartment of Clinical and Biological Sciences, Laboratory of Molecular Virology and Antiviral Research, University of Turin, S. Luigi Gonzaga HospitalDepartment of Clinical and Biological Sciences, Laboratory of Molecular Virology and Antiviral Research, University of Turin, S. Luigi Gonzaga HospitalDepartment of Clinical and Biological Sciences, Laboratory of Molecular Virology and Antiviral Research, University of Turin, S. Luigi Gonzaga HospitalVaccine & Gene Therapy Institute, Oregon Health & Science UniversityVaccine & Gene Therapy Institute, Oregon Health & Science UniversityInstitute of Materials and Interfaculty Bioengineering Institute, École polytechnique fédérale de LausanneInstitute of Materials and Interfaculty Bioengineering Institute, École polytechnique fédérale de LausanneDepartment of Biological and Environmental Science/Nanoscience Center, University of JyväskylaVaccine & Gene Therapy Institute, Oregon Health & Science UniversityDepartment of Clinical and Biological Sciences, Laboratory of Molecular Virology and Antiviral Research, University of Turin, S. Luigi Gonzaga HospitalInstitute of Materials and Interfaculty Bioengineering Institute, École polytechnique fédérale de LausanneInstituut-Lorentz for theoretical physics, Leiden UniversityFondazione I.R.C.C.S. Istituto Neurologico Carlo BestaKeeping viral vaccines cold from the manufacturers to patients is problematic and costly. Here, Krol and others show additives that can significantly improve at very low concentrations the storage of adenovirus type 5 at ambient and elevated temperature.https://doi.org/10.1038/ncomms13520
collection DOAJ
language English
format Article
sources DOAJ
author Maria Pelliccia
Patrizia Andreozzi
Jayson Paulose
Marco D’Alicarnasso
Valeria Cagno
Manuela Donalisio
Andrea Civra
Rebecca M. Broeckel
Nicole Haese
Paulo Jacob Silva
Randy P. Carney
Varpu Marjomäki
Daniel N. Streblow
David Lembo
Francesco Stellacci
Vincenzo Vitelli
Silke Krol
spellingShingle Maria Pelliccia
Patrizia Andreozzi
Jayson Paulose
Marco D’Alicarnasso
Valeria Cagno
Manuela Donalisio
Andrea Civra
Rebecca M. Broeckel
Nicole Haese
Paulo Jacob Silva
Randy P. Carney
Varpu Marjomäki
Daniel N. Streblow
David Lembo
Francesco Stellacci
Vincenzo Vitelli
Silke Krol
Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months
Nature Communications
author_facet Maria Pelliccia
Patrizia Andreozzi
Jayson Paulose
Marco D’Alicarnasso
Valeria Cagno
Manuela Donalisio
Andrea Civra
Rebecca M. Broeckel
Nicole Haese
Paulo Jacob Silva
Randy P. Carney
Varpu Marjomäki
Daniel N. Streblow
David Lembo
Francesco Stellacci
Vincenzo Vitelli
Silke Krol
author_sort Maria Pelliccia
title Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months
title_short Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months
title_full Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months
title_fullStr Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months
title_full_unstemmed Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months
title_sort additives for vaccine storage to improve thermal stability of adenoviruses from hours to months
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-11-01
description Keeping viral vaccines cold from the manufacturers to patients is problematic and costly. Here, Krol and others show additives that can significantly improve at very low concentrations the storage of adenovirus type 5 at ambient and elevated temperature.
url https://doi.org/10.1038/ncomms13520
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