Multiple Epistasis Interactions Within MHC Are Associated With Ulcerative Colitis

Multiple Epistasis Interactions Within MHC Are Associated With Ulcerative Colitis

Successful searching for epistasis is much challenging, which generally requires very large sample sizes and/or very dense marker information. We exploited the largest Crohn's disease (CD) dataset (18,000 cases + 34,000 controls) and ulcerative colitis (UC) dataset (14,000 cases + 34,000 contro...

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Bibliographic Details
Main Authors: Jie Zhang, Zhi Wei, Christopher J. Cardinale, Elena S. Gusareva, Kristel Van Steen, Patrick Sleiman, International IBD Genetics Consortium, Hakon Hakonarson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Genetics
Subjects:
epistasis
genome-wide association study
immunochip
major histocompatibility complex
ulcerative colitis
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00257/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00257/full

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