COVID‐19 hypothesis: Activated protein C for therapy of virus‐induced pathologic thromboinflammation

Abstract Seriously ill patients with coronavirus disease 2019 (COVID‐19) at risk for death exhibit elevated cytokine and chemokine levels and D‐dimer, and they often have comorbidities related to vascular dysfunctions. In preclinical studies, activated protein C (APC) provides negative feedback down...

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Bibliographic Details
Main Authors: John H. Griffin, Patrick Lyden
Format: Article
Language:English
Published: Wiley 2020-05-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
Online Access:https://doi.org/10.1002/rth2.12362