Genetic and Epigenetic Inactivation of Kruppel-like Factor 4 in Medulloblastoma

Genetic and Epigenetic Inactivation of Kruppel-like Factor 4 in Medulloblastoma

Although medulloblastoma is the most common pediatric malignant brain tumor, its molecular underpinnings are largely unknown. We have identified rare, recurrent homozygous deletions of Kruppel-like Factor 4 (KLF4) in medulloblastoma using high-resolution single nucleotide polymorphism arrays, digit...

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Bibliographic Details
Main Authors: Yukiko Nakahara, Paul A. Northcott, Meihua Li, Paul N. Kongkham, Christian Smith, Hai Yan, Sidney Croul, Young-Shin Ra, Charles Eberhart, Annie Huang, Darell Bigner, Wesia Grajkowska, Timothy Van Meter, James T. Rutka, Michael D. Taylor
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558610800818

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http://www.sciencedirect.com/science/article/pii/S1476558610800818

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