The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

Low density lipoprotein (LDL) cholesterol is taken up into cells via clathrin-mediated endocytosis of the LDL receptor (LDLR). Following dissociation of the LDLR-LDL complex, LDL is directed to lysosomes whereas the LDLR recycles to the plasma membrane. Activation of the sterol-sensing nuclear recep...

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Bibliographic Details
Main Authors: Vincenzo Sorrentino, Jessica K. Nelson, Elena Maspero, André R.A. Marques, Lilith Scheer, Simona Polo, Noam Zelcer
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Journal of Lipid Research
Subjects:
liver X receptor
low density lipoprotein receptor
inducible degrader of low density lipoprotein receptor
E3-ubiquitin ligase
endocytosis
lipoprotein receptors
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520375337

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http://www.sciencedirect.com/science/article/pii/S0022227520375337

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