Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment

Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment

Summary: Hematopoietic stem cells (HSCs) are considered a heterogeneous cell population. To further resolve the HSC compartment, we characterized a retinoic acid (RA) reporter mouse line. Sub-fractionation of the HSC compartment in RA-CFP reporter mice demonstrated that RA-CFP-dim HSCs were largely...

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Main Authors: Felicia Kathrine Bratt Lauridsen, Tanja Lyholm Jensen, Nicolas Rapin, Derya Aslan, Anna Sofia Wilhelmson, Sachin Pundhir, Matilda Rehn, Franziska Paul, Amir Giladi, Marie Sigurd Hasemann, Palle Serup, Ido Amit, Bo Torben Porse
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718309847

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http://www.sciencedirect.com/science/article/pii/S2211124718309847

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