Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling

Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling

PDZ domain-containing proteins are known to function as intracellular scaffolds. Here, Egea-Jimenez et al. report the structure of the tandem PDZ domains of syntenin in complex with a Frizzled 7 peptide and PIP2, show that the ligands bind to syntenin cooperatively and illustrate the role of the com...

Full description

Bibliographic Details
Main Authors: Antonio Luis Egea-Jimenez, Rodrigo Gallardo, Abel Garcia-Pino, Ylva Ivarsson, Anna Maria Wawrzyniak, Rudra Kashyap, Remy Loris, Joost Schymkowitz, Frederic Rousseau, Pascale Zimmermann
Format: Article
Language:English
Published: Nature Publishing Group 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12101

Internet

https://doi.org/10.1038/ncomms12101

Similar Items