How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology

How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology

Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation, and may also accumulate within LBs in Parkinson's disease (PD) and other synucleinopathies. Therefore, the development of...

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Bibliographic Details
Main Authors: Senthil T. Kumar, Somanath Jagannath, Cindy Francois, Hugo Vanderstichele, Erik Stoops, Hilal A. Lashuel
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Neurobiology of Disease
Subjects:
α-Synuclein
Parkinson's disease
Conformational antibodies
Oligomers
Binding specificity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120303612

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http://www.sciencedirect.com/science/article/pii/S0969996120303612

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