Human bronchial epithelial cell‐derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF‐β‐WNT crosstalk

Human bronchial epithelial cell‐derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF‐β‐WNT crosstalk

Abstract Idiopathic pulmonary fibrosis (IPF) is characterized by devastating and progressive lung parenchymal fibrosis, resulting in poor patient prognosis. An aberrant recapitulation of developmental lung gene expression, including genes for transforming growth factor (TGF)‐β and WNT, has been wide...

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Bibliographic Details
Main Authors: Tsukasa Kadota, Yu Fujita, Jun Araya, Naoaki Watanabe, Shota Fujimoto, Hironori Kawamoto, Shunsuke Minagawa, Hiromichi Hara, Takashi Ohtsuka, Yusuke Yamamoto, Kazuyoshi Kuwano, Takahiro Ochiya
Format: Article
Language:English
Published: Taylor & Francis Group 2021-08-01
Series:Journal of Extracellular Vesicles
Subjects:
exosome
lung epithelial cell
mesenchymal stem cell
pulmonary fibrosis
senescence
Online Access:https://doi.org/10.1002/jev2.12124

Internet

https://doi.org/10.1002/jev2.12124

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