In Vitro Inhibitory Effects of APINACA on Human Major Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Drug Transporters

In Vitro Inhibitory Effects of APINACA on Human Major Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Drug Transporters

APINACA (known as AKB48, <i>N</i>-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide), an indazole carboxamide synthetic cannabinoid, has been used worldwide as a new psychoactive substance. Drug abusers take various drugs concomitantly, and therefore, it is necessary to characterize the p...

Full description

Bibliographic Details
Main Authors: Sunjoo Kim, Won-Gu Choi, Mihwa Kwon, Sowon Lee, Yong-Yeon Cho, Joo Young Lee, Han Chang Kang, Im-Sook Song, Hye Suk Lee
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Molecules
Subjects:
APINACA
drug–drug interaction
cytochrome P450
uridine 5′-diphospho-glucuronosyltransferases
drug transporters
Online Access:https://www.mdpi.com/1420-3049/24/16/3000

Internet

https://www.mdpi.com/1420-3049/24/16/3000

Similar Items