Transthyretin Amyloid Fibril Disrupting Activities of Extracts and Fractions from <i>Juglans mandshurica</i> Maxim. var. <i>cordiformis</i> (Makino) Kitam.

Transthyretin Amyloid Fibril Disrupting Activities of Extracts and Fractions from <i>Juglans mandshurica</i> Maxim. var. <i>cordiformis</i> (Makino) Kitam.

Transthyretin-related amyloidosis is a slowly progressive disorder caused by deposition of insoluble amyloid plaques formed by fibrillization of mutant or defective transthyretin (TTR) monomers that leads to neurodegeneration and organ failure. Thus, any compound exhibiting TTR amyloid formation inh...

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Bibliographic Details
Main Authors: Niraj Chaudhary, Ryoko Sasaki, Tsuyoshi Shuto, Masato Watanabe, Teppei Kawahara, Mary Ann Suico, Takeshi Yokoyama, Mineyuki Mizuguchi, Hirofumi Kai, Hari Prasad Devkota
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Molecules
Subjects:
transthyretin-related amyloidosis
transthyretin protein (TTR)
<i>Juglans mandshurica</i> var. <i>sachalinensis</i>
<i>Juglans mandshurica</i> var. <i>cordiformis</i>
naphthoquinone
juglone
Online Access:https://www.mdpi.com/1420-3049/24/3/500

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https://www.mdpi.com/1420-3049/24/3/500

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