Retinal Distribution and Extracellular Activity of Granzyme B: A Serine Protease That Degrades Retinal Pigment Epithelial Tight Junctions and Extracellular Matrix Proteins

Retinal Distribution and Extracellular Activity of Granzyme B: A Serine Protease That Degrades Retinal Pigment Epithelial Tight Junctions and Extracellular Matrix Proteins

Granzymes are a family of serine proteases first shown to be intracellular initiators of immune-mediated cell death in target pathogenic cells. In addition to its intracellular role, Granzyme B (GzmB) has important extracellular functions in immune regulation and extracellular matrix (ECM) degradati...

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Bibliographic Details
Main Authors: Joanne A. Matsubara, Yuan Tian, Jing Z. Cui, Matthew R. Zeglinski, Sho Hiroyasu, Christopher T. Turner, David J. Granville
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
ZO-1
blood-eye barrier
Bruch's membrane
geographic atrophy
soft drusen
choroidal neovascularization
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00574/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00574/full

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