Semen inhibits Zika virus infection of cells and tissues from the anogenital region
Semen from Zika virus infected individuals can contain high viral loads and can result in sexual transmission. Here, Müller et al. show that semen, and particularly seminal preparations containing extracellular vesicles, inhibit infection of Zika and other flaviviruses.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04442-y |
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doaj-6c32bac538ea4152bde13f0d2dad20ed2021-05-11T09:24:25ZengNature Publishing GroupNature Communications2041-17232018-06-019111410.1038/s41467-018-04442-ySemen inhibits Zika virus infection of cells and tissues from the anogenital regionJanis A. Müller0Mirja Harms1Franziska Krüger2Rüdiger Groß3Simone Joas4Manuel Hayn5Andrea N. Dietz6Sina Lippold7Jens von Einem8Axel Schubert9Manuela Michel10Benjamin Mayer11Mirko Cortese12Karen S. Jang13Nathallie Sandi-Monroy14Miriam Deniz15Florian Ebner16Olli Vapalahti17Markus Otto18Ralf Bartenschlager19Jean-Philippe Herbeuval20Jonas Schmidt-Chanasit21Nadia R. Roan22Jan Münch23Institute of Molecular Virology, Ulm University Medical CenterInstitute of Molecular Virology, Ulm University Medical CenterInstitute of Molecular Virology, Ulm University Medical CenterInstitute of Molecular Virology, Ulm University Medical CenterInstitute of Molecular Virology, Ulm University Medical CenterInstitute of Molecular Virology, Ulm University Medical CenterInstitute of Virology, Ulm University Medical CenterInstitute of Virology, Ulm University Medical CenterInstitute of Virology, Ulm University Medical CenterInstitute of Virology, Ulm University Medical CenterInstitute of Virology, Ulm University Medical CenterInstitute of Epidemiology and Medical Biometry, Ulm UniversityDepartment of Infectious Diseases, Molecular Virology, Medical Faculty, Heidelberg UniversityGladstone Institute of Virology and ImmunologyInstitute of Molecular Virology, Ulm University Medical CenterKlinik für Frauenheilkunde und Geburtshilfe, Ulm University Medical CenterKlinik für Frauenheilkunde und Geburtshilfe, Ulm University Medical CenterDepartment of Virology and Immunology, University of Helsinki and Helsinki University HospitalDepartment of Neurology, Ulm UniversityDepartment of Infectious Diseases, Molecular Virology, Medical Faculty, Heidelberg UniversityChemistry, Biology, Modeling and Immunotherapy (CBMIT), CNRS, UMR8601, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université Paris Descartes, CICB ParisBernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and ResearchGladstone Institute of Virology and ImmunologyInstitute of Molecular Virology, Ulm University Medical CenterSemen from Zika virus infected individuals can contain high viral loads and can result in sexual transmission. Here, Müller et al. show that semen, and particularly seminal preparations containing extracellular vesicles, inhibit infection of Zika and other flaviviruses.https://doi.org/10.1038/s41467-018-04442-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Janis A. Müller Mirja Harms Franziska Krüger Rüdiger Groß Simone Joas Manuel Hayn Andrea N. Dietz Sina Lippold Jens von Einem Axel Schubert Manuela Michel Benjamin Mayer Mirko Cortese Karen S. Jang Nathallie Sandi-Monroy Miriam Deniz Florian Ebner Olli Vapalahti Markus Otto Ralf Bartenschlager Jean-Philippe Herbeuval Jonas Schmidt-Chanasit Nadia R. Roan Jan Münch |
| spellingShingle |
Janis A. Müller Mirja Harms Franziska Krüger Rüdiger Groß Simone Joas Manuel Hayn Andrea N. Dietz Sina Lippold Jens von Einem Axel Schubert Manuela Michel Benjamin Mayer Mirko Cortese Karen S. Jang Nathallie Sandi-Monroy Miriam Deniz Florian Ebner Olli Vapalahti Markus Otto Ralf Bartenschlager Jean-Philippe Herbeuval Jonas Schmidt-Chanasit Nadia R. Roan Jan Münch Semen inhibits Zika virus infection of cells and tissues from the anogenital region Nature Communications |
| author_facet |
Janis A. Müller Mirja Harms Franziska Krüger Rüdiger Groß Simone Joas Manuel Hayn Andrea N. Dietz Sina Lippold Jens von Einem Axel Schubert Manuela Michel Benjamin Mayer Mirko Cortese Karen S. Jang Nathallie Sandi-Monroy Miriam Deniz Florian Ebner Olli Vapalahti Markus Otto Ralf Bartenschlager Jean-Philippe Herbeuval Jonas Schmidt-Chanasit Nadia R. Roan Jan Münch |
| author_sort |
Janis A. Müller |
| title |
Semen inhibits Zika virus infection of cells and tissues from the anogenital region |
| title_short |
Semen inhibits Zika virus infection of cells and tissues from the anogenital region |
| title_full |
Semen inhibits Zika virus infection of cells and tissues from the anogenital region |
| title_fullStr |
Semen inhibits Zika virus infection of cells and tissues from the anogenital region |
| title_full_unstemmed |
Semen inhibits Zika virus infection of cells and tissues from the anogenital region |
| title_sort |
semen inhibits zika virus infection of cells and tissues from the anogenital region |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-06-01 |
| description |
Semen from Zika virus infected individuals can contain high viral loads and can result in sexual transmission. Here, Müller et al. show that semen, and particularly seminal preparations containing extracellular vesicles, inhibit infection of Zika and other flaviviruses. |
| url |
https://doi.org/10.1038/s41467-018-04442-y |
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